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Can we genetically improve humans using George Church’s famous list?

Columnist Michael Le Page delves into a catalogue of hundreds of potentially beneficial gene mutations and variants that is popular with transhumanists

In the world of transhumanism, the idea of enhancing human capabilities through technology and science is gaining momentum. And one of the most talked-about topics in this field is the potential of gene mutations and variants to improve our lives. Columnist Michael Le Page has recently explored this topic in depth, delving into a catalogue of hundreds of potentially beneficial gene mutations and variants that has captured the attention of transhumanists.

The catalogue in question is the Human Gene Mutation Database (HGMD), which contains information on over 200,000 genetic mutations and variants. While this database has been around for over two decades, it has recently gained popularity among transhumanists who see it as a treasure trove of possibilities for human enhancement.

One of the main reasons for this interest is the fact that many of these mutations and variants have been linked to positive traits and abilities. For example, there are mutations that have been associated with increased muscle mass, improved memory, and even resistance to diseases. And with the advancements in gene editing technology, the possibility of harnessing these mutations for human enhancement is becoming more and more feasible.

But what exactly are these mutations and variants, and how can they benefit us? Le Page explains that they are essentially changes in the DNA sequence that can result in altered proteins or gene expression. While some mutations can have negative effects, there are also many that can have positive impacts on our health and abilities.

One of the most well-known examples of a beneficial gene mutation is the CCR5-delta32 mutation, which has been linked to resistance to HIV. This mutation is found in around 10% of Europeans and is believed to have originated as a defense mechanism against the bubonic plague. With the potential to protect against a deadly virus, it’s no wonder that this mutation has captured the attention of transhumanists.

But it’s not just about disease resistance. The HGMD also contains information on mutations and variants that can enhance our physical and mental abilities. For instance, there are mutations that have been linked to increased muscle strength and endurance, improved cognitive function, and even enhanced senses. These are all traits that transhumanists believe can be harnessed to push the boundaries of human potential.

Of course, the idea of manipulating our genes for enhancement purposes raises ethical concerns. But Le Page argues that the potential benefits of these mutations cannot be ignored. He points out that many of the traits associated with these mutations are already being pursued through other means, such as exercise and brain training. So why not explore the possibility of using gene editing to achieve these goals more efficiently and effectively?

Moreover, the HGMD also contains information on mutations and variants that can help us understand and treat genetic disorders. By studying these mutations, scientists can gain valuable insights into the underlying causes of these disorders and develop targeted treatments. This could potentially improve the lives of millions of people who suffer from genetic conditions.

But it’s not just about treating disorders. Transhumanists also see the potential for these mutations to enhance our overall well-being and quality of life. By harnessing these mutations, we could potentially live longer, healthier lives with improved physical and mental abilities.

However, it’s important to note that the HGMD is not a magic solution for human enhancement. There are still many challenges and limitations to overcome before we can fully harness the potential of these mutations. And as with any new technology, there are ethical considerations that must be carefully addressed.

But the fact remains that the HGMD is a valuable resource for understanding and potentially enhancing the human genome. And as Le Page concludes, “the potential of these mutations to improve our lives is too great to ignore.” With continued research and responsible use, these mutations and variants could pave the way for a brighter future for humanity.

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